What Is The Best Prescription For Eczema – Doctors prescribe the drug to adults, teenagers and older children with chronic or acute illnesses. Now, they can consider it for young people suffering from bright and shiny skin diseases.
One of the most frustrating things about having a child with atopic dermatitis (eczema) is figuring out how to help them when treatments don’t work. Now there is a new option to try Dupixent (dupilumab), a monthly vaccine that parents can give to children at home.
What Is The Best Prescription For Eczema
In June 2022, the US Food and Drug Administration (FDA) approved Dupixent for the treatment of severe atopic dermatitis in children 6 months to 5 years of age. and corticosteroid creams or ointments, according to the statement. From drug makers, Sanofi and Regeneron.
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According to the American Academy of Dermatology (AAD), more than 1 in 10 Americans have atopic dermatitis, which usually occurs in children and develops before age 5.
According to the National Eczema Association (NEA), about one-third of children with atopic dermatitis have moderate to severe disease.
“Atopic dermatitis is a widespread disease associated with a high burden of disease in patients and caregivers and many studies show a negative impact on quality of life and economic costs,” says Vice Zelma Chiesa Fuxench, professor of dermatology at the University. . Perelman School of Medicine in Philadelphia, Pennsylvania.
“However, treatment options for patients with atopic dermatitis, especially pediatric patients under 5 years of age, are limited, and until recently, there was no FDA-approved option for this condition. This year we,” Dr. Fuxench.
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In infants and young children, atopic dermatitis can cause a rash that feels dry, raw, and itchy, similar to AAD. The affected area may be very itchy and ooze or weep. It’s not uncommon for children to have skin infections, trouble sleeping, or make a fuss when they have eczema.
For young children, using a mild soap immediately with moisturizer can prevent burns and keep skin cool, according to the NEA. Adding half a cup of bleach to the bath can help reduce inflammation that sometimes worsens eczema symptoms.
According to the NEA, over-the-counter medications such as petroleum jelly or a mild corticosteroid cream can sometimes control symptoms. Stronger forms of corticosteroids are also recommended for infants and children.
Dupixent offers another option. First approved for adults five years ago and more recently for teenagers and children over 5 years of age, Dupixent belongs to a family of drugs called biologics, which are drugs derived from cells. Cells designed to target certain aspects of the organism or drug. immune system system.
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The immune system can cause chronic conditions such as atopic dermatitis. Dupixent suppresses the immune system by preventing a type of protein called interleukin from binding to cell receptors, according to the NEA.
In a clinical trial reviewed by the FDA as part of the approval process for patients younger than 5 years of age, patients received a topical corticosteroid every four weeks for 16 weeks, or in combination with Dupixent. More than half of the children were treated with corticosteroids. And Dupixent achieved an infection rate of at least 75 percent by the end of the trial, according to data shared by the drug companies.
With topical corticosteroids and Dupixent, 28 percent of children achieved complete or nearly clear skin by the end of the trial, compared with 4 percent of children who used topical corticosteroids alone. And, 48 percent of patients on topical corticosteroids and Dupixent experienced a significant reduction in pain, compared with 9 percent of those on corticosteroids alone.
Saxon Smith, PhD, a dermatologist and clinical professor at the Australian School of Medicine in Canberra, says: “Itch can have a negative impact on a child’s sleep, which can have a negative impact on work or everyday life.
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“Addressing this through effective disease management can change the lives of these young patients,” said Dr. Smith.
According to company data, the side effects of dupixent after one year were similar to those seen in elderly patients with atopic dermatitis. Among patients aged 6 to 5 years, 5 percent of those tested had hand, foot, and mouth disease, a common disease in children, and 2 percent had skin papilloma, an improvement—no skin cancer.
These side effects did not cause younger patients to stop treatment with Dupixent in the trial, the company said.
“Overall, dupilumab has demonstrated a good and consistent safety profile in populations including children, and studies in adults have shown that this safety profile is consistent over time,” said Dr. Syor. Fuxench. “However, more long-term data are needed, especially for children who have recently been approved for this drug.”
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How long children should stay on Dupixent is an open question. Adults with severe atopic dermatitis may need to take these medications for years, if not their entire lives, to maintain symptom relief, Fuxench said.
“For younger kids, it can be a different ball game for a lot of reasons,” Fuchsench said. Some young patients may outgrow their disease, ending the need for this drug. By using Dupixent it is possible to prevent future exacerbations of eczema, avoiding the need for lifelong treatment.
Although there is uncertainty about long-term use, it is reasonable for parents of children with eczema to ask their doctor about Dupixent if other symptoms are not being used to control the child’s disease,’ advises Fuxench.
“I don’t think dupilumab is the first choice for most patients because most pediatric patients have mild disease that can be managed with mild chemotherapy and occasional chemotherapy,” he said. “But it is a palliative treatment option for uncontrolled patients.”
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